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KMID : 0869620010180030367
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Journal of Korean Society of Hospital Pharmacists
2001 Volume.18 No. 3 p.367 ~ p.371
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Stability of High-concentration Dopamine Hydrochloride in 5% Dextrose
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최미현/Choi, Mi Hyun
조은경/김재연/조영환/노환성/Cho, Eun Kyung/Kim, Jae Youn/Cho, Young Hwan/Ro, Hwan Seong
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Abstract
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Dopamine, the precursor of norepinephrine, is used in acute heart failure, cardiogenic shock, and oliguria. Dopamine is administered as the hydrochloride by intravenous infusion diluted in 5% dextrose, 0.9% sodium chloride, or other suitable diluents. Usually dopamine HCI is available for infusion in concentration of 0.8, 1.6, and 3.2 ㎎/㎖ in dextrose 5%. But, in the ICU, the more concentrated 4, 8, rarely 16 ㎎/㎖ solutions may be preferred in patients who are to be fluid-restricted or to whom a slower rate of infusion is desired. Therefore we studied the stability of high-concentration dopamine HCI in 5% dextrose at ambient temperature through evaluating the contents of dopamine by HPLC method and confirmed pH and osmotic values. The results showed that the t_(90)(C_(t)>90% C_(O)) of dopamine HCl solutions was 33.63, 29.75, and 25.79 hrs for the 4, 8, and 16 ㎎/㎖ concentrations, respectively. In conclusion, each solution was stable for at least 24 hrs. Small decrease in pH was observed for the 48-hour study period. But, during that times the osmolarity in each concentration was not significantly different.
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